2000, Volume 3, Issue 1, Pages 28 - 33

Review

Models for studying benign prostatic hyperplasia W Mahapokai1,4,5, FJ van Sluijs1 & JA Schalken1,2,3 1Department of Clinical Sciences of Companion Animals, Utrecht University, Utrecht, The Netherlands     2Department of Urology, University Hospital Nijmegen; Nijmegen, The Netherlands     3Department of Veterinary Pathology, Utrecht University, Utrecht, The Netherlands     4Department of Veterinary Surgery, Khon-Kaen University, Thailand     5Current address: Department of Veterinary Surgery, Khon-Kaen University, Khon-Kaen 40002, Thailand.     Correspondence to: W Mahapokai, Department of Clinical Sciences of Companion Animals, Yalelaan 8, 3584 CM Utrecht, The Netherlands. E-mail: w.mahapokai@vet.uu.nl

Keywords

benign prostatic hyperplasia;   models;   in vivo;   in vitro

Abstract

Benign prostatic hyperplasia (BPH) is one of the most common diseases affecting aging man. Attempts have been made to clarify the etiology and pathogenesis and, to that end, experimental models have been developed. To date, in vitro and in vivo models have been used, depending on the concept of the study. Spontaneous animal models are limited to the chimpanzee and the dog. Ethical and financial factors restrict the applicability of these models. The hormonal-induced canine BPH model is a good alternative that closely resembles human BPH in many aspects. The experimental models currently used for studying BPH are reviewed. Prostate Cancer and Prostatic Diseases (2000) 3, 28-33

Received 17 January 2000; Accepted 28 January 2000

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