2000, Volume 3, Issue 1, Pages 53 - 56

Case Report

Postradiation therapy adenosquamous cell carcinoma of the prostate M Helal1, JI Diaz2, A Tannenbaum1, H Greenberg3 & J Lockhart1 1Division of Urology, Department of Surgery, H. Lee Moffitt Cancer Center and Research Institute at the University of South Florida College of Medicine, Tampa, Florida, USA     2Department of Pathology, H. Lee Moffitt Cancer Center and Research Institute at the University of South Florida College of Medicine, Tampa, Florida, USA     3Department of Radiation Oncology, H. Lee Moffitt Cancer Center and Research Institute at the University of South Florida College of Medicine, Tampa, Florida, USA     Correspondence to: JI Diaz, Department of Pathology and Surgery, Division of Urology, H. Lee Moffitt Cancer Center & Research Institute, University of South Florida, College of Medicine, 12902 Magnolia Drive, Tampa, FL 33612, USA.

Keywords

postradiation;   adenosquamous cell carcinoma

Abstract

The objective of this study was to present two cases of adenosquamous cell carcinoma of the prostate following radiation therapy. Two patients with history of prostate cancer treated with radiation therapy presented with rectal bleeding and a large ulcerated rectal mass. The rectal biopsy revealed on both cases squamous cell carcinoma. The initial diagnosis was invasive squamous cell carcinoma from anal origin. Both patients underwent pelvic exenteration with continent urinary diversion. After extensive histological sampling and immuno-histochemisty, they were correctly diagnosed of adenosquamous cell carcinoma of the prostate with invasion of the rectum. The patients died 6 and 16 months after surgery with widespread metastases. A review of the literature is presented. Adenosquamous cell carcinoma of the prostate is an unusual histological variant of prostate cancer. To our knowledge, only three cases of adenosquamous cell carcinoma of the prostate following radiation therapy have been reported. The unusual clinical and histopathological features of the two cases reported here led to an initial mistaken diagnosis. Adenosquamous cell carcinoma of the prostate should be considered in the differential diagnosis when a patient with prostate cancer develops a rectal mass or rectal bleeding following radiation therapy and the rectal biopsy reveals squamous cell carcinoma. Prostate Cancer and Prostatic Diseases (2000) 3, 53-56

Received 23 November 1999; Revised 16 February 2000; Accepted 21 February 2000

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