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Leukemia
Normal and Malignant Hemopoiesis

December 2000, Volume 14, Issue 12
Table of Contents

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Editorial

The dilemma of apoptosis in myelodysplasia and leukemia: a new promise of therapeutic intervention? 2017
MV Blagosklonny
Full Article (PDF)

Spotlight on Apoptosis

Review
Kinases: positive and negative regulators of apoptosis 2019
RA Franklin & JA McCubrey
Abstract    Full Article (PDF)

Review and Meeting Report

Dissecting the pathways to death 2035
PT Daniel
Abstract    Full Article (PDF)

Original Manuscripts

Apoptosis
Expression and activity of caspases 1 and 3 in myelodysplastic syndromes 2045
D Boudard, O Sordet, C Vasselon, V Revol, M-F Berthéas, D Freyssenet, A Viallet, S Piselli, D Guyotat & L Campos
Abstract    Full Article (PDF)

Therapy
Idarubicin intensified BUCY2 regimen in allogeneic unmanipulated transplant for high-risk hematological malignancies 2052
A Mengarelli, AP Iori, C Guglielmi, MP Perrone, M Gozzer, C Girmenia, G Cimino, AM Testi, R Ricci, L De Felice, G Girelli, F Mandelli & W Arcese
Abstract    Full Article (PDF)

Prognosis in AML
Prognosis of patients with a second relapse of acute myeloid leukemia 2059
B Stoiser, P Knöbl, C Fonatsch, OA Haas, G Mitterbauer, A Weltermann, K Geissler, P Valent, W Sperr, I Pabinger, K Lechner & U Jaeger
Abstract    Full Article (PDF)

Autologous Bone Marrow Transplantation in CML
Late autologous transplantation in chronic myelogenous leukemia with peripheral blood progenitor cells mobilized by G-CSF and interferon-alpha 2064
M Michallet, A Thiébaut, I Philip, C Charrin, C Vigouroux, X Thomas, K Bilger, A Belhabri, D Guyotat, B Corront, B Salles, C Dumontet, PY Péaud, JP Vilque, A Devidas & D Fière
Abstract    Full Article (PDF)

Clinical Laboratory Correlates in AML
Protean clinical manifestations in children with leukemias containing MLL-AF10 fusion 2070
L Gore, J Ess, MA Bitter, L McGavran, L Meltesen, Q Wei & SP Hunger
Abstract    Full Article (PDF)

Disease- and treatment-related elevation of the neurodegenerative marker tau in children with hematological malignancies 2076
SW Van Gool, E Van Kerschaver, P Brock, H Pottel, F Hulstaert, E Vanmechelen, A Uyttebroeck, A Van De Voorde & H Vanderstichele
Abstract    Full Article (PDF)

Sensitivity and Resistance to Therapy
Phase I study of cinchonine, a multidrug resistance reversing agent, combined with the CHVP regimen in relapsed and refractory lymphoproliferative syndromes 2085
E Solary, L Mannone, D Moreau, D Caillot, R-O Casasnovas, H Guy, M Grandjean, J-E Wolf, F André, P Fenaux, P Canal, B Chauffert, A Wotawa, M Bayssas & P Genne
Abstract    Full Article (PDF)

Studies on B Cell Precursors
Notch-1 and Notch-2 exhibit unique patterns of expression in human B-lineage cells 2095
FE Bertrand, CE Eckfeldt, AS Lysholm & TW LeBien
Abstract    Full Article (PDF)

Fine characterization of childhood and adult acute lymphoblastic leukemia (ALL) by a proB and preB surrogate light chain-specific mAb and a proposal for a new B cell ALL classification 2103
B Lemmers, C Arnoulet, C Fossat, H Chambost, D Sainty, J Gabert & C Schiff
Abstract    Full Article (PDF)

Signal Transduction
A transient dephosphorylation of JAK1 and JAK2 characterises the early-phase response of murine erythroleukemia cells to the differentiation inducer hexamethylenebisacetamide 2112
A Arcangeli, L Fontana, O Crociani, A Cherubini, G Hofmann, E Piccini, S Polvani, M D’Amico, M Carlà & M Olivotto
Abstract    Full Article (PDF)

Modifications in phospholipase D activity and isoform expression occur upon maturation and differentiation in vivo and in vitro in human myeloid cells 2118
M El Marjou, V Montalescot, A Buzyn & B Geny
Abstract    Full Article (PDF)

Tumor Suppressor Genes in AML
Human mortalin (HSPA9): a candidate for the myeloid leukemia tumor suppressor gene on 5q31 2128
H Xie, Z Hu, B Chyna, SK Horrigan & CA Westbrook
Abstract    Full Article (PDF)

Cell Cycle and Progenitors
Proliferative status of primitive hematopoietic progenitors from patients with acute myelogenous leukemia (AML) 2135
Y Guan & DE Hogge
Abstract    Full Article (PDF)

Lymphoma
Genetic instability is associated with histological transformation of follicle center lymphoma 2142
M Nagy, M Balázs, Z Ádám, Z Petkó, B Tímár, Z Szereday, T László, RA Warnke & A Matolcsy
Abstract    Full Article (PDF)

Resistance to CD95-mediated apoptosis through constitutive c-FLIP expression in a non-Hodgkin’s lymphoma B cell line 2149
M Irisarri, J Plumas, T Bonnefoix, M-C Jacob, C Roucard, M-A Pasquier, J-J Sotto & A Lajmanovich
Abstract    Full Article (PDF)

A prospective study of intensive induction therapy with high-dose consolidation in patients with aggressive non-Hodgkin’s lymphoma and two or three adverse prognostic factors 2159
C Dumontet, C Thieblemont, D Espinouse, F Bouafia, O Hequet, G Salles & B Coiffier
Abstract    Full Article (PDF)

Bio-Technical Methods Section (BTS)

mRNA expression levels of methotrexate resistance-related proteins in childhood leukemia as determined by a standardized competitive template-based RT-PCR method 2166
MG Rots, JC Willey, G Jansen, CH Van Zantwijk, P Noordhuis, JP DeMuth, E Kuiper, AJP Veerman, R Pieters & GJ Peters
Abstract    Full Article (PDF)

Detection of hTERT protein by flow cytometry 2176
ASM Ali, R Chopra, J Robertson & NG Testa
Abstract    Full Article (PDF)

Extensive characterization of dendritic cells generated in serum-free conditions: regulation of soluble antigen uptake, apoptotic tumor cell phagocytosis, chemotaxis and T cell activation during maturation in vitro 2182
K Tarte, G Fiol, J-F Rossi & B Klein
Abstract    Full Article (PDF)

Spotlight on Long-Term Results of Pediatric ALL Clinical Trials from 12 Study Groups World Wide

Long-term results of large prospective trials in childhood acute lymphoblastic leukemia 2193
M Schrappe, B Camitta & C-H Pui
Full Article (PDF)

Note from the Editor 2195
N Muller-Bérat, MD
Full Article (PDF)

Original Manuscripts

Long-term results of the Italian Association of Pediatric Hematology and Oncology (AIEOP) Acute Lymphoblastic Leukemia Studies, 1982-1995 2196
V Conter, M Aricò, MG Valsecchi, G Basso, A Biondi, E Madon, F Mandelli, G Paolucci, A Pession, C Rizzari, R Rondelli, L Zanesco & G Masera for the Associazione Italiana di Ematologia ed Oncologia Pediatrica (AIEOP)
Abstract    Full Article (PDF)

Long-term results of four consecutive trials in childhood ALL performed by the ALL-BFM study group from 1981 to 1995 2205
M Schrappe, A Reiter, M Zimmermann, J Harbott, W-D Ludwig, G Henze, H Gadner, E Odenwald & H Riehm
Abstract    Full Article (PDF)

Children’s Cancer Group trials in childhood acute lymphoblastic leukemia: 1983-1995 2223
PS Gaynon, ME Trigg, NA Heerema, MG Sensel, HN Sather, GD Hammond & WA Bleyer
Abstract    Full Article (PDF)

Co-operative study group for childhood acute lymphoblastic leukemia (COALL): long-term follow-up of trials 82, 85, 89 and 92 2234
DO Harms & GE Janka-Schaub on behalf of the COALL Study Group
Abstract    Full Article (PDF)

Long-term follow-up of Dutch Childhood Leukemia Study Group (DCLSG) protocols for children with acute lymphoblastic leukemia, 1984-1991 2240
WA Kamps, AJP Veerman, ER van Wering, JF van Weerden, R Slater & A van der Does-van den Berg
Abstract    Full Article (PDF)

Results of Dana-Farber Cancer Institute Consortium protocols for children with newly diagnosed acute lymphoblastic leukemia (1981-1995) 2247
LB Silverman, L Declerck, RD Gelber, V Kimball Dalton, BL Asselin, RD Barr, LA Clavell, CA Hurwitz, A Moghrabi, Y Samson, MA Schorin, JM Lipton, HJ Cohen & SE Sallan
Abstract    Full Article (PDF)

Long-term results of three randomized trials (58831, 58832, 58881) in childhood acute lymphoblastic leukemia: a CLCG-EORTC report 2257
E Vilmer, S Suciu, A Ferster, Y Bertrand, H Cavé, A Thyss, Y Benoit, N Dastugue, M Fournier, G Souillet, A-M Manel, A Robert, B Nelken, F Millot, P Lutz, X Rialland, F Mechinaud, P Boutard, C Behar, J-M Chantraine, E Plouvier, G Laureys, P Brock, A Uyttebroeck, G Margueritte, D Plantaz, L Norton, N Francotte, J Gyselinck, C Waterkeyn, G Solbu, N Philippe & J Otten
Abstract    Full Article (PDF)

Improving outcome through two decades in childhood ALL in the Nordic countries: the impact of high-dose methotrexate in the reduction of CNS irradiation 2267
G Gustafsson, K Schmiegelow, E Forestier, N Clausen, A Glomstein, G Jonmundsson, L Mellander, A Mäkipernaa, R Nygaard & UM Saarinen-Pihkala on behalf of the Nordic Society of Pediatric Haematology and Oncology (NOPHO)
Abstract    Full Article (PDF)

Long-term results of treatment studies for childhood acute lymphoblastic leukemia: Pediatric Oncology Group studies from 1986-1994 2276
KW Maloney, JJ Shuster, S Murphy, J Pullen & BA Camitta
Abstract    Full Article (PDF)

Long-term results of Total Therapy studies 11, 12 and 13A for childhood acute lymphoblastic leukemia at St Jude Children’s Research Hospital 2286
C-H Pui, JM Boyett, GK Rivera, ML Hancock, JT Sandlund, RC Ribeiro, JE Rubnitz, FG Behm, SC Raimondi, A Gajjar, B Razzouk, D Campana, LE Kun, MV Relling & WE Evans
Abstract    Full Article (PDF)

Long-term follow-up of childhood acute lymphoblastic leukemia in Tokyo Children’s Cancer Study Group 1981-1995 2295
M Tsuchida, K Ikuta, R Hanada, T Saito, K Isoyama, K Sugita, Y Toyoda, A Manabe, K Koike, A Kinoshita, M Maeda, K Ishimoto, T Sato, Y Okimoto, T Kaneko, M Kajiwara, M Sotomatsu, Y Hayashi, H Yabe, R Hosoya, Y Hoshi, M Ohira, F Bessho, Y Tsunematsu, I Tsukimoto & S Nakazawa for the Tokyo Children's Cancer Study Group
Abstract    Full Article (PDF)

Long-term follow-up of the United Kingdom Medical Research Council protocols for childhood acute lymphoblastic leukaemia, 1980-1997 2307
OB Eden, G Harrison, S Richards, JS Lilleyman, CC Bailey, JM Chessells, IM Hann, FGH Hill & BES Gibson on behalf of the Medical Research Council Childhood Leukaemia Working Party
Abstract    Full Article (PDF)

Correspondence

An unusual presentation of a case of T cell angiotropic (intravascular) lymphoma 2321
G Isimbaldi, L Corral, S Songia, MG Valente, S De Bianchi & A Biondi
Full Article (PDF)

Intrathecal mitozantrone has to be prohibited 2323
JH Dalle, A Lambilliotte, AS Defachelles, F Mazingue & B Nelken
Full Article (PDF)

Is there any genetic susceptibility to acute promyelocytic leukemia? 2324
X Thomas
Full Article (PDF)

Author Index

2327
Full Article (PDF)

Keyword Index

2337
Full Article (PDF)

© Macmillan Publishers Ltd 2000

Nature Publishing Group Specialist Journals have a substantial list of leading international journals in the key areas of science and medicine. Specialist fields covered include: bone marrow transplantation, cell death and differentiation, critical care/intensive care, dentistry, dentomaxillofacial radiology, environmental epidemiology, gene therapy, hematology, human and experimental toxicology, exposure analysis, human hypertension, impotence research, industrial microbiology, industrial health, information systems, leukemia, lupus, microcirculation, molecular psychiatry, multiple sclerosis, neuroscience, nursing, nutrition, obesity, occupational medicine, oncology, oncology pharmacy practice, operations research, optometry and ophthalmology, oral diseases, orthopedics, paraplegia, perinatology, pharmacology, psychiatry, public health, spinal injury and disease.